Rol' Mikrobnykh Metabolitov V Disfunktsii Mitokhondriy Pri Sepsise. Fedotcheva Nadezhda
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Author: Fedotcheva Nadezhda
Page Count: 96 pages
Published Date: 23 Jul 2013
Publisher: LAP Lambert Academic Publishing
Publication Country: United States
Language: English, Russian
ISBN: 9783659431111
File Name: Rol'.Mikrobnykh.Metabolitov.V.Disfunktsii.Mitokhondriy.Pri.Sepsise.pdf
Download Link: Rol' Mikrobnykh Metabolitov V Disfunktsii Mitokhondriy Pri Sepsise
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Problema sepsisa s kazhdym godom stanovitsya vse bolee aktual'noy. Mekhanizmy poliorgannoy nedostatochnosti, razvivayushcheysya u bol'nykh s sepsisom, nakhodyatsya v tsentre vnimaniya issledovateley samykh raznykh spetsial'nostey. Monografiya posvyashchena issledovaniyu roli mitokhondriy i mikrobnykh metabolitov v etikh protsessakh. Avtorami vpervye predlozhena gipoteza o nalichii svyazi mezhdu metabolicheskoy aktivnost'yu mikrobioty cheloveka i funktsional'noy aktivnost'yu mitokhondriy v tkanyakh. Predstavleny dannye eksperimental'nykh i klinicheskikh issledovaniy o vidospetsifichnoy produktsii nizkomolekulyarnykh aromaticheskikh kislot v krovi pri sepsise, issledovano ikh vliyanie na osnovnye funktsii mitokhondriy: dykhanie, fosforilirovanie, regulyatsiyu mitokhondrial'noy pory, produktsiyu aktivnykh form kisloroda. Prodemonstrirovana obratimost' indutsirovannoy mikrobnymi metabolitami disfunktsii mitokhondriy. Prognoziruetsya, chto nizkomolekulyarnye mikrobnye metabolity mogut sluzhit' biomarkerami sepsisa, a mitokhondrii mishen'yu dlya korrektsii poliorgannoy nedostatochnosti. Kniga prednaznachena dlya issledovateley v oblasti fundamental'noy meditsiny i klinitsistov.
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